FOR RESOLVING MILD, MODERATE AND SEVERE DEPRESSION

General Description

Avea is an extract produced from the root of Curcuma longa, commonly known as turmeric. Turmeric has long been used in both Ayurvedic and Chinese medicine as an anti-inflammatory, to treat digestive disorders and liver problems, and for the treatment of skin diseases and wound healing. Recent published studies have been addressing the anti-depressant properties of Avea. Via the proprietary extraction and enhancement process utilized to produce Avea, the product has been enhanced to address the majority of the causes of endogenous depression. Patients suffering from depression report relief within a few hours to a few days after starting the use of Avea.

Some Reported Medicinal Properties

ANTIDEPRESSANT

ANTI-INFLAMMATORY

ANTIMICROBIAL

ANTIMUTAGENIC

ANTIOXIDANT

ANTITUMOR

CHOLECYSTOKINETIC

DEPURATIVE

FUMITORY

HEMOSTATIC

Medical Conditions [peer-reviewed journals]

CANCER

Kuttan, R., Bhanumathy, P., Nirmala, K., & George, M. C. (1985). Potential anticancer activity of turmeric (Curcuma longa). Cancer Letters, 29(2), 197-202. Full Article

DEPRESSION

Yu, Z. F., Kong, L. D., & Chen, Y. (2002). Antidepressant activity of aqueous extracts of Curcuma longa in mice. Journal of Ethnopharmacology, 83(1-2), 161-165. Full Article

Fan, C., Song, Q., Wang, P., Li, Y., Yu, S. Y., & Yang,M. (2018). Neuroprotective effects of curcumin on IL-1β-induced neuronal apoptosis and depression-like behaviors caused by chronic stressin rats. Frontiers in cellular neuroscience, 12,516. Full Article

Ashraf, K. (2018). A comprehensive review on Curcuma longa Linn.: Phytochemical, pharmacological, and molecular study. InternationalJournal of Green Pharmacy (IJGP), 11(04). Full Article

Fusar-Poli, L., Vozza, L., Gabbiadini, A., Vanella, A., Concas,I., Tinacci, S., ... & Aguglia, E. (2019). Curcumin for depression: a meta-analysis. Critical reviews in food science andnutrition, 1-11. Full Article

DIABETES

Kuroda, M., Mimaki, Y., Nishiyama, T., Mae, T., Kishida, H., Tsukagawa, M., ... & Kitahara, M. (2005). Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biological and Pharmaceutical Bulletin, 28(5), 937-939. Full Article

Reddy, A. C. P., & Lokesh, B. R. (1994). Effect of dietary turmeric (Curcuma longa) on iron-induced lipid peroxidation in the rat liver. Food and Chemical Toxicology, 32(3), 279-283. Full Article

HEPATITIS B

Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., ... & Ahn, J. K. (2009). Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. Journal of Ethnopharmacology, 124(2), 189-196. Full Article

LUNG CANCER

Mohammad, P., Nosratollah, Z., Mohammad, R., Abbas, A., & Javad, R. (2010). The inhibitory effect of Curcuma longa extract on telomerase activity in A549 lung cancer cell line. African Journal of Biotechnology, 9(6), 912-919. Full Article

MOOD ALTERING

Ross, S. M. (2018). Curcuma longa (Theracumin®): A Bioavailable Form of Curcumin and Its Cognitive Benefits. Holistic nursing practice, 32(4),217-220. Full Article

ULCERS

Kim, D. C., Kim, S. H., Choi, B. H., Baek, N. I., Kim, D., Kim, M. J., & Kim, K. T. (2005). Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biological and Pharmaceutical Bulletin, 28(12), 2220-2224. Full Article

Prucksunand, C., Indrasukhsri, B., Leethochawalit, M., & Hungspreugs, K. (2001). Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn.) on healing of peptic ulcer. Southeast Asian Journal of Tropical Medicine and Public Health, 32(1), 208-215. Full Article

URINARY TRACT INFECTION (UTI)

Gul, N., Mujahid, T. Y., Jehan, N., & Ahmad, S. (2004). Studies on the Antibacterial Effect of Curcuma longa Against Urinary Tract Infection Isolates. Pakistan Journal of Biological Sciences, 7(12), 2055-2060. Full Article

TARDIVE DYSKINESIA (TD)

Bishnoi, M., Chopra, K., & Kulkarni, S. K. (2008). Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain. Pharmacology Biochemistry and Behavior, 88(4), 511-522. Full Article

TUMORS

Jiang, J. L., Jin, X. L., Zhang, H., Su, X., Qiao, B., & Yuan, Y. J. (2012). Identification of antitumor constituents in curcuminoids from Curcuma longa L. based on the composition–activity relationship. Journal of Pharmaceutical and Biomedical Analysis, 70, 664-670. Full Article

Kim, J. H., Gupta, S. C., Park, B., Yadav, V. R., & Aggarwal, B. B. (2012). Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)‐κB and NF‐κB‐regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis. Molecular Nutrition & Food Research, 56(3), 454-465. Full Article

Medicinal Properties [peer-reviewed journals]

ANTHELMINTIC ACTIVITY

Singh, R., Mehta, A., Mehta, P., & Shukla, K. (2011). Anthelmintic activity of rhizome extracts of Curcuma longa and Zingiber officinale (Zingiberaceae). International Journal of Pharmacy and Pharmaceutical Sciences, 3(2), 236-237. Full Article

ANTIBACTERIAL

Packiavathy, I. A. S. V., Priya, S., Pandian, S. K., & Ravi, A. V. (2014). Inhibition of biofilm development of uropathogens by curcumin–an anti-quorum sensing agent from Curcuma longa. Food Chemistry, 148, 453-460. Full Article

Singh, S., Sankar, B., Rajesh, S., Sahoo, K., Subudhi, E., & Nayak, S. (2011). Chemical composition of turmeric oil (Curcuma longa L. cv. Roma) and its antimicrobial activity against eye infecting pathogens. Journal of Essential Oil Research, 23(6), 11-18. Full Article

Lee, K. H., Kim, B. S., Keum, K. S., Yu, H. H., Kim, Y. H., Chang, B. S., ... & You, Y. O. (2011). Essential oil of Curcuma longa inhibits Streptococcus mutans biofilm formation. Journal of Food Science, 76(9), H226-H230. Full Article

Naz, S., Jabeen, S., Ilyas, S., Manzoor, F., Aslam, F., & Ali, A. (2010). Antibacterial activity of Curcuma longa varieties against different strains of bacteria. Pak J Bot, 42(1), 455-62. Full Article

Kim, K. J., Yu, H. H., Cha, J. D., Seo, S. J., Choi, N. Y., & You, Y. O. (2005). Antibacterial activity of Curcuma longa L. against methicillin‐resistant Staphylococcus aureus. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 19(7), 599-604. Full Article

Singh, R., Chandra, R., Bose, M., & Luthra, P. M. (2002). Antibacterial activity of Curcuma longa rhizome extract on pathogenic bacteria. Current Science, 737-740. Full Article

ANTICONVULSANT

Orellana-Paucar, A. M., Serruys, A. S. K., Afrikanova, T., Maes, J., De Borggraeve, W., Alen, J., ... & Esguerra, C. V. (2012). Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models. Epilepsy & Behavior, 24(1), 14-22. Full Article

ANTIOXIDANT

Kim, Y., You, Y., Yoon, H. G., Lee, Y. H., Kim, K., Lee, J., ... & Jun, W. (2014). Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. Food Chemistry, 151, 148-153. Full Article

Salama, S. M., Abdulla, M. A., AlRashdi, A. S., Ismail, S., Alkiyumi, S. S., & Golbabapour, S. (2013). Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complementary and Alternative Medicine, 13(1), 56. Full Article

Gounder, D. K., & Lingamallu, J. (2012). Comparison of chemical composition and antioxidant potential of volatile oil from fresh, dried and cured turmeric (Curcuma longa) rhizomes. Industrial Crops and Products, 38, 124-131. Full Article

Lim, H. S., Park, S. H., Ghafoor, K., Hwang, S. Y., & Park, J. (2011). Quality and antioxidant properties of bread containing turmeric (Curcuma longa L.) cultivated in South Korea. Food Chemistry, 124(4), 1577-1582. Full Article

Maizura, M., Aminah, A., & Wan Aida, W. M. (2011). Total phenolic content and antioxidant activity of kesum (Polygonum minus), ginger (Zingiber officinale) and turmeric (Curcuma longa) extract. International Food Research Journal, 18(2). Full Article

Lee, H. S., Li, L., Kim, H. K., Bilehal, D., Li, W., Lee, D. S., & Kim, Y. H. (2010). The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. Journal of Microbiology and Biotechnology, 20(9), 1331-1338. Full Article

Singh, G., Kapoor, I. P. S., Singh, P., De Heluani, C. S., De Lampasona, M. P., & Catalan, C. A. (2010). Comparative study of chemical composition and antioxidant activity of fresh and dry rhizomes of turmeric (Curcuma longa Linn.). Food and Chemical Toxicology, 48(4), 1026-1031. Full Article

Kumar, A., Dogra, S., & Prakash, A. (2009). Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behavioural Brain Research, 205(2), 384-390. Full Article

Cousins, M., Adelberg, J., Chen, F., & Rieck, J. (2007). Antioxidant capacity of fresh and dried rhizomes from four clones of turmeric (Curcuma longa L.) grown in vitro. Industrial Crops and Products, 25(2), 129-135. Full Article

Kumar, G. S., Nayaka, H., Dharmesh, S. M., & Salimath, P. V. (2006). Free and bound phenolic antioxidants in amla (Emblica officinalis) and turmeric (Curcuma longa). Journal of Food Composition and Analysis, 19(5), 446-452. Full Article

Mohanty, I., Arya, D. S., Dinda, A., Joshi, S., Talwar, K. K., & Gupta, S. K. (2004). Protective effects of Curcuma longa on ischemia-reperfusion induced myocardial injuries and their mechanisms. Life Sciences, 75(14), 1701-1711. Full Article

Braga, M. E., Leal, P. F., Carvalho, J. E., & Meireles, M. A. A. (2003). Comparison of yield, composition, and antioxidant activity of turmeric (Curcuma longa L.) extracts obtained using various techniques. Journal of Agricultural and Food Chemistry, 51(22), 6604-6611. Full Article

Quiles, J. L., Mesa, M. D., Ramírez-Tortosa, C. L., Aguilera, C. M., Battino, M., Gil, Á., & Ramírez-Tortosa, M. C. (2002). Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(7), 1225-1231. Full Article

Ramsewak, R. S., DeWitt, D. L., & Nair, M. G. (2000). Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I–III from Curcuma longa. Phytomedicine, 7(4), 303-308. Full Article

Selvam, R., Subramanian, L., Gayathri, R., & Angayarkanni, N. (1995). The anti-oxidant activity of turmeric (Curcuma longa). Journal of Ethnopharmacology, 47(2), 59-67. Full Article

ANTIMICROBIAL

Parveen, Z., Nawaz, S., Siddique, S., & Shahzad, K. (2013). Composition and antimicrobial activity of the essential oil from leaves of Curcuma longa L. Kasur variety. Indian Journal of Pharmaceutical Sciences, 75(1), 117. Full Article

Lawhavinit, O. A., Kongkathip, N., & Kongkathip, B. (2010). Antimicrobial activity of curcuminoids from Curcuma longa L. on pathogenic bacteria of shrimp and chicken. Kasetsart Journal—Natural Science, 44(3), 364-371. Full Article

Sathishkumar, M., Sneha, K., & Yun, Y. S. (2010). Immobilization of silver nanoparticles synthesized using Curcuma longa tuber powder and extract on cotton cloth for bactericidal activity. Bioresource Technology, 101(20), 7958-7965. Full Article

Sunilson, J. A. J., Suraj, R., Rejitha, G., Anandarajagopal, K., Kumari, A. V. A. G., & Promwichit, P. (2009). In vitro antimicrobial evaluation of Zingiber officinale, Curcuma longa and Alpinia galanga extracts as natural food preservatives. American Journal of Food Technology, 4(5), 192-200. Full Article

Niamsa, N., & Sittiwet, C. (2009). Antimicrobial activity of Curcuma longa aqueous extract. Journal of Pharmacology and Toxicology, 4(4), 173-177. Full Article

ANTI-INFLAMMATORY

Bagad, A. S., Joseph, J. A., Bhaskaran, N., & Agarwal, A. (2013). Comparative evaluation of anti-inflammatory activity of curcuminoids, turmerones, and aqueous extract of Curcuma longa. Advances in Pharmacological Sciences, 2013. Full Article

Anna, K. T., Suhana, M. E., Das, S., Faizah, O., & Hamzaini, A. H. (2011). Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: an anatomico-radiological study. Clin Ter, 162(3), 201-207. Full Article

Ramadan, G., Al-Kahtani, M. A., & El-Sayed, W. M. (2011). Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation, 34(4), 291-301. Full Article

Jurenka, J. S. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative Medicine Review, 14(2). Full Article

Gupta, S. K., Agarwal, R., Srivastava, S., Agarwal, P., Agrawal, S. S., Saxena, R., & Galpalli, N. (2008). The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits.Investigative Ophthalmology & Visual Science, 49(9), 4036-4040. Full Article

Camacho-Barquero, L., Villegas, I., Sánchez-Calvo, J. M., Talero, E., Sánchez-Fidalgo, S., Motilva, V., & de la Lastra, C. A. (2007). Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. International Immunopharmacology, 7(3), 333-342. Full Article

Chainani-Wu, N. (2003). Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). The Journal of Alternative & Complementary Medicine, 9(1), 161-168. Full Article

Gupta, B., & Ghosh, B. (1999). Curcuma longa inhibits TNF-α induced expression of adhesion molecules on human umbilical vein endothelial cells. International Journal of Immunopharmacology, 21(11), 745-757. Full Article

ANTIFUNGAL

Koo, B. S., Lee, W. C., Chung, K. H., Ko, J. H., & Kim, C. H. (2004). A water extract of Curcuma longa L.(Zingiberaceae) rescues PC12 cell death caused by pyrogallol or hypoxia/reoxygenation and attenuates hydrogen peroxide induced injury in PC12 cells. Life Sciences, 75(19), 2363-2375. Full Article

Apisariyakul, A., Vanittanakom, N., & Buddhasukh, D. (1995). Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). Journal of Ethnopharmacology, 49(3), 163-169. Full Article

ANTISCHISTOSOMAL

EL-Ansary, A. K., Ahmed, S. A., & Aly, S. A. (2007). Antischistosomal and liver protective effects of Curcuma longa extract in Schistosoma mansoni infected mice. Indian Journal of Experimental Biology, 45, 791-801. Full Article

CARDIOPROTECTIVE EFFECTS

El-Sayed, E. M., El-azeem, A. S. A., Afify, A. A., Shabana, M. H., & Ahmed, H. H. (2011). Cardioprotective effects of Curcuma longa L. extracts against doxorubicin-induced cardiotoxicity in rats. Journal of Medicinal Plants Research, 5(17), 4049-4058. Full Article

NEUROPROTECTIVE

Rajakrishnan, V., Viswanathan, P., Rajasekharan, K. N., & Menon, V. P. (1999). Neuroprotective role of curcumin from Curcuma longa on ethanol‐induced brain damage. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 13(7), 571-574. Full Article

IMMUNOSTIMULATORY

Yue, G. G., Chan, B. C., Hon, P. M., Kennelly, E. J., Yeung, S. K., Cassileth, B. R., ... & Lau, C. B. (2010). Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. International Journal of Biological Macromolecules, 47(3), 342-347. Full Article

IMMUNOMODULATORY

Sengupta, M., Sharma, G. D., & Chakraborty, B. (2011). Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pacific Journal of Tropical Biomedicine, 1(3), 193. Full Article

Yue, G. G., Chan, B. C., Hon, P. M., Lee, M. Y., Fung, K. P., Leung, P. C., & Lau, C. B. (2010). Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food and Chemical Toxicology, 48(8-9), 2011-2020. Full Article

Madan, B., Gade, W. N., & Ghosh, B. (2001). Curcuma longa activates NF-κB and promotes adhesion of neutrophils to human umbilical vein endothelial cells. Journal of Ethnopharmacology, 75(1), 25-32. Full Article

VARIOUS PROPERTIES

Liju, V. B., Jeena, K., & Kuttan, R. (2011). An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian Journal of Pharmacology, 43(5), 526. Full Article

Araujo, C. A. C., & Leon, L. L. (2001). Biological activities of Curcuma longa L. Memórias de Instituto Oswaldo Cruz, 96(5), 723-728. Full Article

Roth, G. N., Chandra, A., & Nair, M. G. (1998). Novel bioactivities of Curcuma longa constituents. Journal of Natural Products, 61(4), 542-545. Full Article

Patient Reports

"I am giving Avea Mood at 20 drops 3 times per day to my daughter who is extremely sick. It combats both natural and induced depression better than any prescription and without the side effects. When we run out, she definitely notices." -R.R.

"My depression kept me from enjoying time with my family. I was always upset by the idea of having to do anything or go anywhere. Once I began taking Avea, my outlook changed and my depression was gone! It really is a great product!"-E.M.

Dosage Information

Mild Depression: take 10 drops in 4 oz. of water 2-4 times per day.

Moderate to Severe Depression: take 10 drops every 15 minutes in 2 oz. of water until symptoms are resolved. Can also put 2 droppers full (approximately 60 drops) in at least 16 oz. (480 ml) of water and sip over a 2-hour period, repeating until symptoms are resolved, then switch to 10 drops in 4 ounces (120 ml) of water 2-4 times per day for maintenance.

Nutramedix, AVEA TURMERIC MOOD SUPPORT Nutramedix, AVEA TURMERIC MOOD SUPPORT